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Most of what we think of cannabinoids occur in CB1 receptors, but CB2 receptors are important in relation to CBD for arthritis because CB2 appears to regulate inflammation.1 In fact, some research suggests that CB2 receptors may be directly implicated in rheumatoid arthritis.2 While CBD doesn’t directly bind to any receptors, it changes how the receptors interact with THC and other cannabinoids, like CBG and CBA

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This has allowed them to adapt successfully to changing consumer tastes, market conditions, and other influences, no matter where they operate